E-ISSN: 1307-394X
Study of VEGF-A Gene Polymorphism in the Patients with Nasopharyngeal Angiofibroma
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Research
VOLUME: 10 ISSUE: 3
P: 0-0
September 2016

Study of VEGF-A Gene Polymorphism in the Patients with Nasopharyngeal Angiofibroma

J Turk Acad Dermatol 2016;10(3):0-0
DOI: 10.6003/jtad.16103a1
Abdurakhmanov Otabek Bakhtiyarovich
1. Tashkent Institute of Postgraduate Medical Education, Uzbekistan
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ABSTRACT

Background:

The vascular endothelial growth factor A (VEGF-A) play a crucial role in development and regulation of activity both of the blood and lymphatic vessels.

Material and Methods:

For definition of the genetic markers C963T, G405C, -1154A of VEGF-A gene we used systems of the genetic analysis PyroMark Q24.

Results:

The analysis of the data has shown that the patients, at the analysis of a genetic marker C963T, have a genotype CC, whereas the given genotype was not found out in the practically healthy people. At genotyping of a marker G405C of VEGF-A gene in group of the patients the increase in frequency of prevalence of a genotype CC (40,0 %) was noted, in comparison with control group (15,0 %). In case of research of G-1154A polymorphism the decrease (10,0 %) in prevalence of a genotype AAi, increase in quantity of detection of a genotype GG (50,0 %) in group of the patients with angiofibroma was observed, in comparison with the control (30,0 % and 10,0 %, respectively).

Conclusion:

Identified VEGF-A gene polymorphism suggests that single nucleotide substitutions in the promoter region of genes are unique and have a definite impact on features of functioning proteins and gene expression.