ABSTRACT

Observations:

A 30 year-old woman with a 6-year history of systemic lupus erythematosus presented with pruritic, erythematous skin rashes on the face, targetoid lesions on the hands and multiple erosions of buccal mucosa. Laboratory investigations showed speckled antinuclear antibody with a titer of 1:320, anti-La (SS-B), anti-Ro (SS-A) antibodies and rheumatoid factor positivity. Histologic examination of lesional skin of the hand was consistent with erythema multiforme. Complete clearing of skin lesions was achieved with oral 80 mg/d prednisolone and 100 mg/d azathioprine within four weeks.