Study of VEGF-A Gene Polymorphism in the Patients with Nasopharyngeal Angiofibroma


  • Abdurakhmanov Otabek Bakhtiyarovich

J Turk Acad Dermatol 2016;10(3):0-0


The vascular endothelial growth factor A (VEGF-A) play a crucial role in development and regulation of activity both of the blood and lymphatic vessels.

Material and Methods:

For definition of the genetic markers C963T, G405C, -1154A of VEGF-A gene we used systems of the genetic analysis PyroMark Q24.


The analysis of the data has shown that the patients, at the analysis of a genetic marker C963T, have a genotype CC, whereas the given genotype was not found out in the practically healthy people. At genotyping of a marker G405C of VEGF-A gene in group of the patients the increase in frequency of prevalence of a genotype CC (40,0 %) was noted, in comparison with control group (15,0 %). In case of research of G-1154A polymorphism the decrease (10,0 %) in prevalence of a genotype AAi, increase in quantity of detection of a genotype GG (50,0 %) in group of the patients with angiofibroma was observed, in comparison with the control (30,0 % and 10,0 %, respectively).


Identified VEGF-A gene polymorphism suggests that single nucleotide substitutions in the promoter region of genes are unique and have a definite impact on features of functioning proteins and gene expression.

Keywords: VEGF-A, nasophagyngeal angiofibroma, gene polymorphism, gene markers, prevalence