Case Report

Nicolau Syndrome


  • Fatih Taştekin
  • Mustafa Ersoy
  • Abdurrahman Aslan
  • Şafak Meriç Özgenel
  • Tuncer Temel
  • Ayşegül Özakyol

J Turk Acad Dermatol 2017;11(2):0-0


Nicolau Syndrome, also known as embolia cutis medicomentosa and livedo-like dermatitis, is a rare cutaneous adverse reaction at the site of intramuscular, intra-articular, subcutaneous injection of particular drugs. Patients complain of severe pain and erythematous-ecchymotic reticular lesions at the injection site. The skin, subcutaneous and muscle tissue necrosis develop as complications of injections.

Our case was a 68 year-old female patient followed with chronic liver disease who developed necrosis of the skin in the right hip after intramuscular diclofenac injection.

Although diclofenac is a widely used non-steroidal anti-inflammatory drug, Nicolau syndrome following intramuscular diclofenac injection has rarely been reported. And also, in our literature examination it is the first case of Nicolau Syndrome with chronic liver dissease.

Keywords: Nicolau Syndrome, Embolia cutis medicomentosa