Background:
The FAS/FASLG system shows a key role in regulating apoptosis.
Objectives:
Previous findings have indicated that a significantly increased risk of vitiligo was associated with FAS-1377 AA genotype and the FAS-1377 AG genotype when compared with FAS- 1377 GG genotype in Chinese population.
Material and Methods:
We investigated the FAS-670, FAS-1377, FAS-844 and FAS-124 polymorphisms in 113 vitiligo patients and also compared 196 controls.
Results:
We found that a significantly increased vitiligo was associated with the FAS-670 GA genotype [adjusted odds ratio (OR), 2.87; 95% confidence interval (CI), 1.37-6.03] when compared with the controls. However, there were no evident risk associated with FAS-1377, 844 and 124 genotypes.
Conclusion:
This is the first report of an association between FAS-670, FAS-1377, FAS-844 and FAS- 124 gene polymorphism and vitiligo in a Turkish population. The results of this study suggest that the presence of FAS-670 GA genotype can be regarded as risk factor for vitiligo, and especially for vitiligo in Turkish population.
Keywords: FAS, gene, polymorphism, vitiligo, Turkish