Assessment of Serum Interleukin-4 and Immunoglobin E Levels in Pityriasis Alba Patients


  • Tahreer A. A. Al-mesari
  • Amal H. A. Gomaa
  • Alaael-din S. Abd-el-hamid
  • Ghada F. A. Mohammed
  • Moustafa M. K. Eyada

J Turk Acad Dermatol 2013;7(2):0-0


Role of IL-4 and Ig-E in aetiopathogenesis of pityriasis alba (PA) is questionable.


To assess the serum IL-4 and Ig-E levels in pityriasis alba patients.

Patients & Methods:

Thirty patients with pityriasis alba (group I) (n=30) and thirty volunteers (group II) completed the study (n=30). IL-4 and Ig-E were measured in patients’ sera with enzyme linked immune sorbent assay (ELISA).


There was statistically significant correlation between IL-4 and PA which points to the role of Th2 and IL-4 in pathogenesis of PA. There was no statistically significance between Ig-E and either PA or IL-4 level.


Imbalance of IL-4 level may play a critical role in pathogenesis of PA. Changed balance of IL-4 level may be related to the genetic background of patients, and adds more evidence to the association of PA and atopic dermatitis.

Keywords: atopic dermatitis, immunoglobin-E, interleukin-4, pityriasis alba.