Apoptotic View to What Happens at Periphery in Psoriasis

  • Semih Tatlıcan
  • Özlem Gülbahar
  • Cemile Eren
  • Fatma Eskioğlu
  • Mehmet Ali Ergun
  • Akın Yılmaz

J Turk Acad Dermatol 2009;3(2):0-0


Psoriasis vulgaris is characterized by T cell alterations both in skin and peripheral blood. There are reports indicating that apoptotic changes in keratinocytes and T lymphocytes may take role in the pathogenesis of psoriasis vulgaris.


The aim of the current study is to find out the apoptotic changes in peripheral lymphocytes of psoriasis patients.

Material and Methods:

57 psoriasis vulgaris and 27 healthy control subjects were included in the study. The levels of caspase-8 and caspase-9 in the sera of the patients and control subjects were measured by Enzyme-linked Immunosorbent Assay (ELISA) method and the number and the percentage of apoptotic lymphocytes were calculated.


General demographic features of the study groups were similar. There was statistically significant difference between the mean apoptotic index of the patients (12.35 ± 3.50) and control group (5.27 ± 1.56), (p=0). The mean caspase-9 levels of the patients (2.2839 ± 0.0653 ng/mL) were also significantly higher than the levels of control subjects (1.9489 ± 0.0214 ng/mL), (p=0.017). The mean caspase-8 levels of the patients (0.1909 ± 0.0653 ng/mL) were significantly lower than the levels of control subjects (0.1919 ± 0.0214 ng/mL), (p=0.042).


Increased apoptosis of peripheral lymphocytes of psoriasis patients can be interpreted as a part of the complex relationship of lymphocytes between periphery and skin. The major pathway of apoptosis in peripheral lymphocytes seems to be the intrinsic pathway as mean caspase- 9 levels were higher and the mean caspase-8 levels were lower than the levels of control subjects.

Keywords: apoptosis, caspases, psoriasis