An Investigation of Efficacy of Topical Niacinamide for the Treatment of Mild and Moderate Acne Vulgaris

  • Yeşim Kaymak
  • Meltem Önder

J Turk Acad Dermatol 2008;2(4):0-0


Niacinamide is a newly-approved anti-acne drug with a potent anti-inflammatory effect. In this study, safety and efficacy of topical 4% niacinamide gel in mild and moderate acne vulgaris was investigated.


Forty-one patients aged 18-25 (mean: 21.6±2.52) with mild and moderate acne vulgaris seen in dermatology outpatient clinic were enrolled in the study. All patients were treated with niacinamide 4% topical gel (Vivatinell Acnecinamide Gel) for eight weeks.


38 patients among 41 were able to complete the treatment. Decrease in the number of pustules comedones and papules were statistically significant at the end of the treatment compared to onset of treatment (p<0.05). Few side effects such as pruritus (n=1) and mild burning (n=3) were observed in very small percentage of patients.


Findings of this study indicate that 4% niacinamide containing gel is effective and safe in alleviating symptoms of mild to moderate acne, with earlier improvement in pustules.

Keywords: niacinamide, acne vulgaris, mild and moderate acne, treatment